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Nucleodur – High Purity Silica for HPLC

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NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties like totally spherical particle shape, outstanding surface smoothness, high pressure stability and low metal content.

NUCLEODUR as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL’s pioneering research in chromatography for more than 40 years and worthy successor of MN’s world famous NUCLEOSIL silica. In RP liquid chromatography the efficiency of the packing is strongly affected by the quality of the base silica itself. Shortcomings in the surface geometry of the particles or metal contaminants are the main reasons for inadequate coverage with the covalently bonded alkylsilanes in the subsequent derivatization steps. It is well known, that poor surface coverage and, in consequence, high activity of residual free silanols often results in peak tailing or adsorption, particularly with basic compounds.

NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties

  • totally spherical particle shape
  • outstanding surface microstructure
  • high pressure stability
  • low metal content

Nucleodur Brochure 

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